Changes in heart rate metrics and physical activity in patients with rare metabolic disorders and healthy controls

Project Description & Objectives

This project aims to use Garmin wearables with the Fitrockr platform to assess changes in heart rate metrics and physical activity in patients with rare metabolic disorders who present with bradycardia or tachycardia at rest and at exercise. The participants in the project include both adult and paediatric patients (6yrs +) who have been referred to a specialist clinic for assessment and treatment. The project also includes assessment in healthy controls that are sex and age matched to the patients. Participants wear a chest-worn heart rate device to determine the comparability with the heart rate measure from the wrist-worn PPG signal. The objectives of the project are:

1. to evaluate differences in heart rate metrics and physical activity levels between patients and sex- and age-matched healthy controls.

2. to measure differences in heart rate metrics and physical activity levels pre- and throughout treatment.

3. to determine if we can replace chest-worn devices with Garmin wrist-worn devices for scaling up in clinical settings.

https://www.mrc-epid.cam.ac.uk/research/measurement-platform/physical-activity-measurement/